Server-based and server-less BYOD solutions to support electronic learning

Over the past 10 years, bring your own device has become an emerging practice across the commercial landscape and has empowered employees to conduct work-related business from the comfort of their own phone, tablet, or other personal electronic device. Currently in the Department of Defense, and specifically the Department of the Navy, no viable solution exists for the delivery of eLearning content to a service member's personal device that satisfy existing policies. The purpose of this thesis is to explore two potential solutions: a server-based method and a server-less method, both of which would allow Marines and Sailors to access eLearning course material by way of their personal devices. This thesis will test the feasibility and functionality of our server-based and server-less solutions by implementing a basic proof of concept for each. The intent is to provide a baseline from which further research and development can be conducted, and to demonstrate how these solutions present a low-risk environment that preserves government network security while still serving as a professional military education force multiplier. Both solutions, while demonstrated with limited prototypes, have the potential to finally introduce bring your own device into the Department of the Navy's eLearning realm.http://archive.org/details/serverbasedndser1094549343Captain, United States Marine CorpsCaptain, United States Marine CorpsApproved for public release; distribution is unlimited

A Multidimensional Conceptualization of Environmental Velocity

Environmental velocity has emerged as an important concept but remains theoretically underdeveloped, particularly with respect to its multidimensionality. In response, we develop a framework that examines the variations in velocity across multiple dimensions of the environment (homology) and the causal linkages between those velocities (coupling). We then propose four velocity regimes based on different patterns of homology and coupling and argue that the conditions of each regime have important implications for organizations

Functional MRI Assessment of Renal Fibrosis in Rat Models

poster abstractIntroduction Renal fibrosis is a common consequence of chronic kidney diseases which affects a large population. Therefore, it is important to establish imaging based noninvasive biomarkers to monitor the progression or regression of renal fibrosis instead of biopsy. Magnetic resonance imaging (MRI) could provide both high spatial resolution and excellent tissue contrast for visualization of kidney morphology. Moreover, MRI is capable of assessing pseudo perfusion (Df) and perfusion fraction (Pf) with intra-voxel incoherent motion (IVIM) imaging (1), tissue oxygenation with T2* mapping (2), macromolecular composition with T1rho imaging (3) and kidney function (eGFR) with dynamic contrast enhanced (DCE) imaging (4). This study is aimed to evaluate the sensitivity of these MRI techniques to the renal fibrotic changes in a rat model. Methods A total of 4 rats were scanned at early (2-5 days) and late (25-35 days) time points after surgical intervention (unilateral ureteral obstruction to induce renal fibrosis) on a Siemens Tim Trio 3T scanner using an 80mm inner diameter 8-channel rat body coil (RAPID, USA) under a stable anesthetized condition. Axial images of 80mm FOV, 2mm slice thick and sub-millimeter in-place resolution were acquired for different functional MRI techniques with following parameters, respectively: IVIM with10 b-values of 0 - 750 s/mm2. T2*: with 10 TEs of 8 - 66 ms; T1rho: with 9 TSL times of 5 - 80 ms; DCE: with150 dynamic measurements at a temporal resolution of 1.01 s. before and after a 15s injection of 1.1 ml GD-DTPA through rat tail with a power injector. Functional data were processed and analyzed using custom MATLAB programs or analysis tools installed in the MRI console workstation. Results Figure 1 shows an anatomical image of the obstructed (R) and healthy (L) rat kidneys. Figures 2-4 show example T1rho map, IVIM Df map, and T2* map, respectively. Quantitative results based on ROI measurements are summarized in table 1. Changes consistent with the expected progression of fibrosis were observed in the obstructed kidney (R) while the healthy kidney (L) and muscle region remained stable. Figure 5 shows the DCE-MRI images at baseline as well as 45s, 95s and 240s after contrast infusion. The timing and intensity of signal changes are clearly different between two kidneys. Quantitative results of DCE-MRI data and comparison with PET study is reported in a separate abstract. Discussion High quality anatomical and functional images of rat kidney can be obtained on a clinical 3.0T MR scanner with dedicated small animal coils and optimized imaging techniques. The findings suggest that IVIM, T2*, T1rho and DCE can be used to assess and monitor different aspects of physiological changes in kidney fibrosis

Discovery of Three Distant, Cold Brown Dwarfs in the WFC3 Infrared Spectroscopic Parallels Survey

We present the discovery of three late type (>T4) brown dwarfs, including a probable Y dwarf, in the WFC3 Infrared Spectroscopic Parallels (WISP) Survey. We use the G141 grism spectra to determine the spectral types of the dwarfs and derive distance estimates based on a comparison with nearby T dwarfs with known parallaxes. These are the most distant spectroscopically confirmed T/Y dwarfs, with the farthest at an estimated distance of ~400 pc. We compare the number of cold dwarfs found in the WISP survey with simulations of the brown dwarf mass function. The number found is generally consistent with an initial stellar mass function dN/dM \propto M^{-\alpha} with \alpha = 0.0--0.5, although the identification of a Y dwarf is somewhat surprising and may be indicative of either a flatter absolute magnitude/spectral type relation than previously reported or an upturn in the number of very late type brown dwarfs in the observed volume.Comment: Accepted for publication by ApJ Letters. 10 pages, 2 figure

Evaluation of 11C-Acetate and 18 F-FDG PET/CT in mouse multidrug resistance gene-2 deficient mouse model of hepatocellular carcinoma

Background Hepatocellular carcinoma (HCC) remains a global health problem with unique diagnostic and therapeutic challenges, including difficulties in identifying the highest risk patients. Previous work from our lab has established the murine multidrug resistance-2 mouse (MDR2) model of HCC as a reasonable preclinical model that parallels the changes seen in human inflammatory associated HCC. The purpose of this study is to evaluate modalities of PET/CT in MDR2−/− mice in order to facilitate therapeutic translational studies from bench to bedside. Methods 18F-FDG and 11C-acetate PET/CT was performed on 12 m MDR2−/− mice (n = 3/tracer) with HCC and 12 m MDR2−/+ control mice (n = 3/tracer) without HCC. To compare PET/CT to biological markers of HCC and cellular function, serum alpha-fetoprotein (AFP), lysophosphatidic acid (LPA), cAMP and hepatic tumor necrosis factor α (TNFα) were quantified in 3-12 m MDR2−/− (n = 10) mice using commercially available ELISA analysis. To translate results in mice to patients 11C-acetate PET/CT was also performed in 8 patents suspected of HCC recurrence following treatment and currently on the liver transplant wait list. Results Hepatic18F-FDG metabolism was not significantly increased in MDR2−/− mice. In contrast, hepatic 11C-acetate metabolism was significantly elevated in MDR2−/− mice when compared to MDR2−/+ controls. Serum AFP and LPA levels increased in MDR2−/− mice contemporaneous with the emergence of HCC. This was accompanied by a significant decrease in serum cAMP levels and an increase in hepatic TNFα. In patients suspected of HCC recurrence there were 5 true positives, 2 true negatives and 1 suspected false 11C-acetate negative. Conclusions Hepatic 11C-acetate PET/CT tracks well with HCC in MDR2−/− mice and patients with underlying liver disease. Consequently 11C-acetate PET/CT is well suited to study 1) HCC emergence/progression in patients and 2) reduce animal numbers required to study new chemotherapeutics in murine models of HCC

Physical Properties of Emission-Line Galaxies at z ~ 2 from Near-Infrared Spectroscopy with Magellan FIRE

We present results from near-infrared spectroscopy of 26 emission-line galaxies at z ~ 2 obtained with the FIRE spectrometer on the Magellan Baade telescope. The sample was selected from the WISP survey, which uses the near-infrared grism of the Hubble Space Telescope Wide Field Camera 3 to detect emission-line galaxies over 0.3 < z < 2.3. Our FIRE follow-up spectroscopy (R~5000) over 1.0-2.5 micron permits detailed measurements of physical properties of the z~2 emission-line galaxies. Dust-corrected star formation rates for the sample range from ~5-100 M_sun yr-1. We derive a median metallicity for the sample of ~0.45 Z_sun, and the estimated stellar masses range from ~10^8.5 - 10^9.5 M_sun. The average ionization parameters measured for the sample are typically much higher than what is found for local star-forming galaxies. We derive composite spectra from the FIRE sample, from which we infer typical nebular electron densities of ~100-400 cm^-3. Based on the location of the galaxies and composite spectra on BPT diagrams, we do not find evidence for significant AGN activity in the sample. Most of the galaxies as well as the composites are offset in the BPT diagram toward higher [O III]/H-beta at a given [N II]/H-alpha, in agreement with other observations of z > 1 star-forming galaxies, but composite spectra derived from the sample do not show an appreciable offset from the local star-forming sequence on the [O III]/H-beta versus [S II]/H-alpha diagram. We infer a high nitrogen-to-oxygen abundance ratio from the composite spectrum, which may contribute to the offset of the high-redshift galaxies from the local star-forming sequence in the [O III]/H-beta versus [N II]/H-alpha diagram. We speculate that the elevated nitrogen abundance could result from substantial numbers of Wolf-Rayet stars in starbursting galaxies at z~2. (Abridged)Comment: Accepted for publication in Ap

Clouds Toward the Virgo Cluster Periphery: Gas-rich Optically Inert Galaxies

Aperture synthesis observations of two HI cloud complexes located in the periphery of the Virgo galaxy cluster are presented. These low HI-mass clouds ($M_{HI}<$ 10$^{9}$) are seen projected on the M region of the western Virgo cluster, where the galaxy population is thought to lie behind the main A cluster surrounding M87. The kinematic measurements of both unresolved Arecibo and resolved VLA-C observations are in good agreement. The HI detections cannot be identified with any optical, IR, or UV emission from available archival imaging. They are inert at these wavelengths. The HI masses of the individual VLA detections range from 7.28 $\leq$ log($M_{HI}) \leq$ 7.85. The total dynamical mass estimates are several times their HI content, ranging from 7.00 $\leq$ log($M_{dyn}) \leq$ 9.07, with the assumption that the clouds are self-gravitating and in dynamical equilibrium. We report the observed parameters derived from the VLA observations. One of these HI clouds appears to be the most isolated optically inert detection observed in the outer reaches of Virgo.Comment: 20 pages, 6 tables, 8 figures, accepted for publication in The Astrophysical Journa

In vivo UTE-MRI reveals positive effects of raloxifene on skeletal bound water in skeletally mature beagle dogs

Raloxifene positively affects mechanical properties of the bone matrix in part through modification of skeletal bound water. The goal of this study was to determine if raloxifene induced alterations in skeletal hydration could be measured in vivo using ultra-short echotime magnetic resonance imaging (UTE-MRI). Twelve skeletally mature female beagle dogs (n=6/group) were treated for 6 months with oral doses of saline vehicle (VEH, 1 ml/kg/day) or raloxifene (RAL, 0.5 mg/kg/day). Following six months of treatment, all animals underwent in vivo UTE-MRI of the proximal tibial cortical bone. UTE-MRI signal intensity versus echotime curves were analyzed by fitting a double exponential to determine the short and long relaxation times of water with the bone (dependent estimations of bound and free water, respectively). Raloxifene-treated animals had significantly higher bound water (+14%; p = 0.05) and lower free water (-20%) compared to vehicle-treated animals. These data provide the first evidence that drug-induced changes in skeletal hydration can be non-invasively assessed using UTE-MRI.Funding for this study was provided by NIH (AR 62002 and a BIRT supplement). Raloxifene was provided by through an MTA with Eli Lilly

Scientific Utopia III: crowdsourcing science

Most scientific research is conducted by small teams of investigators who together formulate hypotheses, collect data, conduct analyses, and report novel findings. These teams operate independently as vertically integrated silos. Here we argue that scientific research that is horizontally distributed can provide substantial complementary value, aiming to maximize available resources, promote inclusiveness and transparency, and increase rigor and reliability. This alternative approach enables researchers to tackle ambitious projects that would not be possible under the standard model. Crowdsourced scientific initiatives vary in the degree of communication between project members from largely independent work curated by a coordination team to crowd collaboration on shared activities. The potential benefits and challenges of large-scale collaboration span the entire research process: ideation, study design, data collection, data analysis, reporting, and peer review. Complementing traditional small science with crowdsourced approaches can accelerate the progress of science and improve the quality of scientific research

The SEGUE Stellar Parameter Pipeline. I. Description and Initial Validation Tests

We describe the development and implementation of the SEGUE (Sloan Extension for Galactic Exploration and Understanding) Stellar Parameter Pipeline (SSPP). The SSPP derives, using multiple techniques, radial velocities and the fundamental stellar atmospheric parameters (effective temperature, surface gravity, and metallicity) for AFGK-type stars, based on medium-resolution spectroscopy and $ugriz$ photometry obtained during the course of the original Sloan Digital Sky Survey (SDSS-I) and its Galactic extension (SDSS-II/SEGUE). The SSPP also provides spectral classification for a much wider range of stars, including stars with temperatures outside of the window where atmospheric parameters can be estimated with the current approaches. This is Paper I in a series of papers on the SSPP; it provides an overview of the SSPP, and initial tests of its performance using multiple data sets. Random and systematic errors are critically examined for the current version of the SSPP, which has been used for the sixth public data release of the SDSS (DR-6).Comment: 64 pages, 8 tables, 12 figures, submitted to the Astronomical Journa